Metoprolol Succinate is a beta blocker widely used for the treatment of hypertension. Its short biological half-life (3-7 Hrs), BCS Class-I and thus frequent administration (usually 3-4 times a day) makes it a suitable candidate for controlled release drug delivery system. So, attempt was to develop a once daily controlled release osmotic drug delivery system. This may offer significant patient compliance by providing enhanced efficacy and reduced side effects and may also reduce the number of daily doses compared to conventional therapies. A 32 factorial design was employed to optimize the amount of osmopolymer (X1) and osmotic agent (X2) as Independent variables that influence the drug release. PPOP tablets of metoprolol succinate were prepared by wet granulation method and evaluated for % cumulative drug release (% CDR) at 8 Hrs as dependent variable (Y). The computer optimization process, contour plots and response surface plots predicted at the concentration of independent variables X1 and X2 (45 mg, and 20 mg respectively), for maximized response. The in-vitro release kinetics studies reveal that optimized batch fits well with Korsmeyer peppas model followed by zero order, hixson crowell, first order and then higuchi’s model. Korsmeyer peppas model analysis indicated that the mechanism of drug release is non-fickian transport. An oral push-pull osmotic system that can deliver metoprolol succinate for extended period of time (12 hr) has been developed and characterized. The developed push-pull osmotic system showed the desired once a daily release kinetic.
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